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Currently, researchers argue that the addition of the features shown here in green have hampered antipsychotic drug research and that reframing the concept of atypicality could have a key role in the advance of this therapeutic field.
Oral aripiprazole is indicated for acute and maintenance treatment of schizophrenia.
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The original study protocols were reviewed and approved by an independent ethics committee or an institutional review board at each study site, and all subjects provided written informed consent before entering the studies.
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Antipsychotic medications may have to be switched during the maintenance phase.
USA as well as in most of the Asia Pacific countries for the acute and maintenance treatment of adults with schizophrenia.
Improvement may continue over 1 year or more of uninterrupted treatment.
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If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking quetiapine or similar medications may increase this risk.
Although specific variants from CACNA1C showed the strongest association when only samples from individuals with bipolar disorder, major depression and schizophrenia were evaluated, the majority of regions seemed to be associated with all 5 disorders, suggesting that common risk alleles contribute to each phenotype, an effect described as pleiotropy.
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Olivares JM, Rodrigues-Morales A, Diels J, Povey M, Jacobs A, Zhao Z, Lam A: Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: Results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR).
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Studies indicate, however, that an integrated approach that includes psychosocial therapy is better at preventing relapses than routine care (medication, monitoring, and access to rehabilitation programs).
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Because of their significant side effects, many patient's stop taking the drug.
Some of the newer agents, however, such as risperidone and its metabolite paliperidone, ziprasidone, lurasidone, aripiprazole, asenapine and iloperidone have clinically-insignificant effects on the receptor and appear to carry a lower risk of insulin resistance.
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Paliperidone works by readjusting the balance of chemicals in the brain that are involved in schizophrenia.
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If you have or have ever had a rare heart problem that may cause fainting or irregular heartbeat (prolonged QT interval) or a heart attack, you should tell your doctor before taking Paliperidone.
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The approval of Invega is exciting as it is the only antipsychotic treatment proven in double-blind, randomized, placebo-controlled trials to be efficacious with a demonstrated tolerable safety profile treating both the psychotic and affective symptoms present in this understudied population.
For this post hoc subgroup comparison, the per-protocol analysis set, originally used only for the primary efficacy analysis, was considered appropriate for analysis of all efficacy and safety assessments as the comparison was exploratory and did not look at early time points.
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Efficacy and safety of direct transition to risperidone long-acting injectable in patients treated with various antipsychotic therapies.
The mean steady-state peak plasma concentration achieved with immediate-release paliperidone was determined to be more than twice the exposure expected with the recommended 12 mg dose.
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This condition is very rare and tends to occur only in very ill psychiatric patients taking multiple psychiatric medications.
Table includes adverse reactions that were reported in 2% or more of subjects in any of the Paliperidone Extended-Release Tablets dose groups and which occurred at greater incidence than in the placebo group.
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SGAs are also used to treat other aspects of the disorder (such as acute bipolar depression or as a prophylactic treatment) as adjuncts or as a monotherapy, depending on the drug.
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Neuroleptic Malignant Syndrome (NMS): NMS, a potentially fatal symptom complex, has been reported with the use of antipsychotic medications.
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Family focused therapy involves education of family members about the disorder and how to provide appropriate support (psycho-education) to their loved one.
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Since the initial stages of antipsychotics (chlorpromazine was released in 1953), it was observed that treatment compliance was difficult to achieve and it was directly related with psychotic relapse and readmission.
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All HCPs and other users of this information agree that they accept responsibility for the use of this program.
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Other ParaGard safety precautions are listed in this article, including warnings of possible ectopic pregnancies and other complications.
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