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If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking quetiapine or similar medications may increase this risk.

Although specific variants from CACNA1C showed the strongest association when only samples from individuals with bipolar disorder, major depression and schizophrenia were evaluated, the majority of regions seemed to be associated with all 5 disorders, suggesting that common risk alleles contribute to each phenotype, an effect described as pleiotropy.

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Olivares JM, Rodrigues-Morales A, Diels J, Povey M, Jacobs A, Zhao Z, Lam A: Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: Results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR).

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The mean steady-state peak plasma concentration achieved with immediate-release paliperidone was determined to be more than twice the exposure expected with the recommended 12 mg dose.

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This condition is very rare and tends to occur only in very ill psychiatric patients taking multiple psychiatric medications.

Table includes adverse reactions that were reported in 2% or more of subjects in any of the Paliperidone Extended-Release Tablets dose groups and which occurred at greater incidence than in the placebo group.

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