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Moreover, whereas a number of non-canonical ligands, including pregnenolone, glucocorticoids, AED, androstenediol, and estradiol can cause promiscuous activation of mutated AR, the 5α-reduced metabolites of 11OH-AED discussed herein have nM activity toward the wild type AR.

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In the UK, patients are often enrolled in large studies coordinated by Cancer Research UK (CRUK), Medical Research Council (MRC), the European Organisation for Research and Treatment of Cancer (EORTC) or the National Cancer Research Network (NCRN).

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